EXTH-01. INHIBITION OF DNA-PKcs BY M3814 POTENTIATES EFFICACY OF IONIZING RADIATION IN PATIENT-DERIVED XENOGRAFTS OF MELANOMA BRAIN METASTASES

Radio-resistance mechanisms limit the benefit of radiation therapy (RT) for melanoma brain metastases. A key pathway for radiation-induced DNA double-strand break repair is non-homologous end joining, which is critically mediated by DNA-dependent protein kinase (DNA-PK(cs)). Here we evaluated radio-...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Ji, Jianxiong, Smith, Emily, Sarkaria, Paige, Mladek, Ann, Talele, Surabhi, Swanson, Katelyn, Mohammad, Afroz S, Zhang, Wenjuan, He, Lihong, Hu, Zeng, Zhao, Yu, Chen, Jiajia, Connors, Margaret A, Porath, Kendra A, Bakken, Katrina K, Dragojevic, Sonja, Carlson, Brett L, Gupta, Shiv K, Burgenske, Danielle M, Kitange, Gaspar J, Elmquist, William F, Sarkaria, Jann
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Preclinical Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651301/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.355
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