EXTH-46. ARTIFICIAL INTELLIGENCE-BASED IDENTIFICATION OF COMBINED VANDETANIB AND EVEROLIMUS IN THE TREATMENT OF ACVR1-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA

Somatic mutations in ACVR1, encoding the serine/threonine kinase ALK2 receptor, are found in a quarter of children with the currently incurable brain tumour diffuse intrinsic pontine glioma (DIPG). Treatment of ACVR1-mutant DIPG patient-derived models with multiple inhibitor chemotypes leads to a re...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Carvalho, Diana, Richardson, Peter, Olaciregui, Nagore Gene, Stankunaite, Reda, Lavarino, Cinzia Emilia, Molinari, Valeria, Corley, Elizabeth, Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence I, Overington, John P, Phelan, Anne, Sheppard, Dave, Mackinnon, Andrew, Hubank, Michael, Cruz, Ofelia, Madrid, Andres Morales La, Mueller, Sabine, Carcaboso, Angel Montero, Carceller, Fernando, Jones, Chris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Preclinical Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651129/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.400
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi