EXTH-46. ARTIFICIAL INTELLIGENCE-BASED IDENTIFICATION OF COMBINED VANDETANIB AND EVEROLIMUS IN THE TREATMENT OF ACVR1-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA

Somatic mutations in ACVR1, encoding the serine/threonine kinase ALK2 receptor, are found in a quarter of children with the currently incurable brain tumour diffuse intrinsic pontine glioma (DIPG). Treatment of ACVR1-mutant DIPG patient-derived models with multiple inhibitor chemotypes leads to a re...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Carvalho, Diana, Richardson, Peter, Olaciregui, Nagore Gene, Stankunaite, Reda, Lavarino, Cinzia Emilia, Molinari, Valeria, Corley, Elizabeth, Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence I, Overington, John P, Phelan, Anne, Sheppard, Dave, Mackinnon, Andrew, Hubank, Michael, Cruz, Ofelia, Madrid, Andres Morales La, Mueller, Sabine, Carcaboso, Angel Montero, Carceller, Fernando, Jones, Chris
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Preclinical Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651129/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.400
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