2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase

Renewed interest in covalent inhibitors of enzymes implicated in disease states has afforded several agents targeted at protein kinases of relevance to cancers. We now report the design, synthesis and biological evaluation of 6-ethynylpurines that act as covalent inhibitors of Nek2 by capturing a cy...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:RSC Med Chem
Päätekijät: Matheson, Christopher J., Coxon, Christopher R., Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M., Hardcastle, Ian R., Harnor, Suzannah J., Mas-Droux, Corine, Newell, David R., Richards, Mark W., Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J., Golding, Bernard T., Cano, Céline
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Royal Society of Chemistry 2020
Aiheet:
Chemistry
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649933/
https://ncbi.nlm.nih.gov/pubmed/33479670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00074d
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