Lataa...
2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase
Renewed interest in covalent inhibitors of enzymes implicated in disease states has afforded several agents targeted at protein kinases of relevance to cancers. We now report the design, synthesis and biological evaluation of 6-ethynylpurines that act as covalent inhibitors of Nek2 by capturing a cy...
Tallennettuna:
| Julkaisussa: | RSC Med Chem |
|---|---|
| Päätekijät: | , , , , , , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Royal Society of Chemistry
2020
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7649933/ https://ncbi.nlm.nih.gov/pubmed/33479670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00074d |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|