2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase

Renewed interest in covalent inhibitors of enzymes implicated in disease states has afforded several agents targeted at protein kinases of relevance to cancers. We now report the design, synthesis and biological evaluation of 6-ethynylpurines that act as covalent inhibitors of Nek2 by capturing a cy...

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Detaylı Bibliyografya
Yayımlandı:RSC Med Chem
Asıl Yazarlar: Matheson, Christopher J., Coxon, Christopher R., Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M., Hardcastle, Ian R., Harnor, Suzannah J., Mas-Droux, Corine, Newell, David R., Richards, Mark W., Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J., Golding, Bernard T., Cano, Céline
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Royal Society of Chemistry 2020
Konular:
Chemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649933/
https://ncbi.nlm.nih.gov/pubmed/33479670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00074d
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