Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine

Nek7 is a serine/threonine-protein kinase required for proper spindle formation and cytokinesis. Elevated Nek7 levels have been observed in several cancers, and inhibition of Nek7 might provide a route to the development of cancer therapeutics. To date, no selective and potent Nek7 inhibitors have b...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Byrne, Matthew J., Nasir, Nazia, Basmadjian, Christine, Bhatia, Chitra, Cunnison, Rory F., Carr, Katherine H., Mas-Droux, Corine, Yeoh, Sharon, Cano, Céline, Bayliss, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2020
Assuntos:
Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200626/
https://ncbi.nlm.nih.gov/pubmed/32242624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200128
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