Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: SAR, structural biology and cellular activity

We report herein a series of Nek2 inhibitors based on an aminopyridine scaffold. These compounds have been designed by combining key elements of two previously discovered chemical series. Structure based design led to aminopyridine (R )-21, a potent and selective inhibitor able to modulate Nek2 acti...

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Detalhes bibliográficos
Main Authors: Innocenti, Paolo, Cheung, Kwai-Ming J., Solanki, Savade, Mas-Droux, Corine, Rowan, Fiona, Yeoh, Sharon, Boxall, Kathy, Westlake, Maura, Pickard, Lisa, Hardy, Tara, Baxter, Joanne E., Aherne, G. Wynne, Bayliss, Richard, Fry, Andrew M., Hoelder, Swen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935458/
https://ncbi.nlm.nih.gov/pubmed/22404346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201683b
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