PTEN Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma

High-grade serous ovarian carcinoma (HGSC) remains a disease with poor prognosis that is unresponsive to current immune checkpoint inhibitors. Although PI3K pathway alterations, such as PTEN loss, are common in HGSC, attempts to target this pathway have been unsuccessful. We hypothesized that aberra...

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Vydáno v:Cancer Res
Hlavní autoři: Spear, Sarah, Le Saux, Olivia, Mirza, Hasan B., Iyer, Nayana, Tyson, Katie, Grundland Freile, Fabio, Walton, Josephine B., Woodman, Chloé, Jarvis, Sheba, Ennis, Darren P., Aguirre Hernandez, Carmen, Xu, Yuewei, Spiliopoulou, Pavlina, Brenton, James D., Costa-Pereira, Ana P., Cook, David P., Vanderhyden, Barbara C., Keun, Hector C., Triantafyllou, Evangelos, Arnold, James N., McNeish, Iain A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for Cancer Research 2024
Témata:
Cancer Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616669/
https://ncbi.nlm.nih.gov/pubmed/39186679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-23-3890
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