CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity

Transplantable murine models of ovarian high grade serous carcinoma (HGSC) remain an important research tool. We previously showed that ID8, a widely-used syngeneic model of ovarian cancer, lacked any of the frequent mutations in HGSC, and used CRISPR/Cas9 gene editing to generate derivatives with d...

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Опубликовано в: :Sci Rep
Главные авторы: Walton, Josephine B., Farquharson, Malcolm, Mason, Susan, Port, Jennifer, Kruspig, Bjorn, Dowson, Suzanne, Stevenson, David, Murphy, Daniel, Matzuk, Martin, Kim, Jaeyeon, Coffelt, Seth, Blyth, Karen, McNeish, Iain A.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715106/
https://ncbi.nlm.nih.gov/pubmed/29203787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17119-1
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