CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity

Transplantable murine models of ovarian high grade serous carcinoma (HGSC) remain an important research tool. We previously showed that ID8, a widely-used syngeneic model of ovarian cancer, lacked any of the frequent mutations in HGSC, and used CRISPR/Cas9 gene editing to generate derivatives with d...

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Vydáno v:Sci Rep
Hlavní autoři: Walton, Josephine B., Farquharson, Malcolm, Mason, Susan, Port, Jennifer, Kruspig, Bjorn, Dowson, Suzanne, Stevenson, David, Murphy, Daniel, Matzuk, Martin, Kim, Jaeyeon, Coffelt, Seth, Blyth, Karen, McNeish, Iain A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715106/
https://ncbi.nlm.nih.gov/pubmed/29203787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17119-1
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