PTEN Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma

High-grade serous ovarian carcinoma (HGSC) remains a disease with poor prognosis that is unresponsive to current immune checkpoint inhibitors. Although PI3K pathway alterations, such as PTEN loss, are common in HGSC, attempts to target this pathway have been unsuccessful. We hypothesized that aberra...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Spear, Sarah, Le Saux, Olivia, Mirza, Hasan B., Iyer, Nayana, Tyson, Katie, Grundland Freile, Fabio, Walton, Josephine B., Woodman, Chloé, Jarvis, Sheba, Ennis, Darren P., Aguirre Hernandez, Carmen, Xu, Yuewei, Spiliopoulou, Pavlina, Brenton, James D., Costa-Pereira, Ana P., Cook, David P., Vanderhyden, Barbara C., Keun, Hector C., Triantafyllou, Evangelos, Arnold, James N., McNeish, Iain A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2024
Assuntos:
Cancer Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616669/
https://ncbi.nlm.nih.gov/pubmed/39186679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-23-3890
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