CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high grade serous carcinoma

Transplantable murine models of ovarian high grade serous carcinoma (HGSC) that recreate key mutations seen in the human disease are greatly needed. These models would assist investigation of the relationship between tumour genotype, chemotherapy response and immune microenvironment. We performed wh...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Walton, Josephine, Blagih, Julianna, Ennis, Darren, Leung, Elaine, Dowson, Suzanne, Farquharson, Malcolm, Tookman, Laura A., Orange, Clare, Athineos, Dimitris, Mason, Susan, Stevenson, David, Blyth, Karen, Strathdee, Douglas, Balkwill, Frances R., Vousden, Karen, Lockley, Michelle, McNeish, Iain A.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802386/
https://ncbi.nlm.nih.gov/pubmed/27530326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1272
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