CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high grade serous carcinoma

Transplantable murine models of ovarian high grade serous carcinoma (HGSC) that recreate key mutations seen in the human disease are greatly needed. These models would assist investigation of the relationship between tumour genotype, chemotherapy response and immune microenvironment. We performed wh...

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Publicado no:Cancer Res
Main Authors: Walton, Josephine, Blagih, Julianna, Ennis, Darren, Leung, Elaine, Dowson, Suzanne, Farquharson, Malcolm, Tookman, Laura A., Orange, Clare, Athineos, Dimitris, Mason, Susan, Stevenson, David, Blyth, Karen, Strathdee, Douglas, Balkwill, Frances R., Vousden, Karen, Lockley, Michelle, McNeish, Iain A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802386/
https://ncbi.nlm.nih.gov/pubmed/27530326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1272
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