CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high grade serous carcinoma

Transplantable murine models of ovarian high grade serous carcinoma (HGSC) that recreate key mutations seen in the human disease are greatly needed. These models would assist investigation of the relationship between tumour genotype, chemotherapy response and immune microenvironment. We performed wh...

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Vydáno v:Cancer Res
Hlavní autoři: Walton, Josephine, Blagih, Julianna, Ennis, Darren, Leung, Elaine, Dowson, Suzanne, Farquharson, Malcolm, Tookman, Laura A., Orange, Clare, Athineos, Dimitris, Mason, Susan, Stevenson, David, Blyth, Karen, Strathdee, Douglas, Balkwill, Frances R., Vousden, Karen, Lockley, Michelle, McNeish, Iain A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802386/
https://ncbi.nlm.nih.gov/pubmed/27530326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1272
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