Reversing Platinum Resistance in High-Grade Serous Ovarian Carcinoma: Targeting BRCA and the Homologous Recombination System

Resistance to platinum chemotherapy is one of the main factors driving ovarian cancer mortality, and overcoming platinum resistance is considered one of the greatest challenges in ovarian cancer research. Genetic and functional evidence points to the homologous recombination (HR) DNA repair system,...

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Autori principali: Wiedemeyer, W. Ruprecht, Beach, Jessica A., Karlan, Beth Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2014
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939430/
https://ncbi.nlm.nih.gov/pubmed/24624361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00034
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