Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance

Although ovarian carcinomas with mutated BRCA1 or BRCA2 are sensitive to platinum compounds, such carcinomas eventually develop platinum resistance. Previously, we showed that acquired resistance to cisplatin in BRCA2-mutated tumors can be mediated by secondary intragenic mutations in BRCA2 that res...

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Bibliographic Details
Main Authors: Swisher, Elizabeth M., Sakai, Wataru, Karlan, Beth Y., Wurz, Kaitlyn, Urban, Nicole, Taniguchi, Toshiyasu
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674369/
https://ncbi.nlm.nih.gov/pubmed/18413725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0088
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