Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

Ovarian carcinomas with mutations in the tumor suppressor BRCA2 are particularly sensitive to platinum compounds 1. However, such carcinomas ultimately develop cisplatin resistance. The mechanism of that resistance is largely unknown 2. Here we show that acquired resistance to cisplatin can be media...

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Bibliografski detalji
Glavni autori: Sakai, Wataru, Swisher, Elizabeth M., Karlan, Beth Y., Agarwal, Mukesh K., Higgins, Jake, Friedman, Cynthia, Villegas, Emily, Jacquemont, Céline, Farrugia, Daniel J., Couch, Fergus J., Urban, Nicole, Taniguchi, Toshiyasu
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577037/
https://ncbi.nlm.nih.gov/pubmed/18264087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06633
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