Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

Ovarian carcinomas with mutations in the tumor suppressor BRCA2 are particularly sensitive to platinum compounds 1. However, such carcinomas ultimately develop cisplatin resistance. The mechanism of that resistance is largely unknown 2. Here we show that acquired resistance to cisplatin can be media...

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Detalhes bibliográficos
Main Authors: Sakai, Wataru, Swisher, Elizabeth M., Karlan, Beth Y., Agarwal, Mukesh K., Higgins, Jake, Friedman, Cynthia, Villegas, Emily, Jacquemont, Céline, Farrugia, Daniel J., Couch, Fergus J., Urban, Nicole, Taniguchi, Toshiyasu
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577037/
https://ncbi.nlm.nih.gov/pubmed/18264087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06633
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