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Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
Ovarian carcinomas with mutations in the tumor suppressor BRCA2 are particularly sensitive to platinum compounds 1. However, such carcinomas ultimately develop cisplatin resistance. The mechanism of that resistance is largely unknown 2. Here we show that acquired resistance to cisplatin can be media...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2008
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577037/ https://ncbi.nlm.nih.gov/pubmed/18264087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06633 |
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