Secondary Somatic Mutations Restoring BRCA1/2 Predict Chemotherapy Resistance in Hereditary Ovarian Carcinomas

PURPOSE: Secondary somatic BRCA1/2 mutations may restore BRCA1/2 protein in hereditary ovarian carcinomas. In cell lines, BRCA2 restoration mediates resistance to platinum chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors. We assessed primary and recurrent BRCA1/2-mutated ovarian carci...

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Detalhes bibliográficos
Main Authors: Norquist, Barbara, Wurz, Kaitlyn A., Pennil, Christopher C., Garcia, Rochelle, Gross, Jenny, Sakai, Wataru, Karlan, Beth Y., Taniguchi, Toshiyasu, Swisher, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2011
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157963/
https://ncbi.nlm.nih.gov/pubmed/21709188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.34.2980
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