The Molecular Pathogenesis of Hereditary Ovarian Carcinoma: Alterations in the Tubal Epithelium of Women with BRCA1 and BRCA2 Mutations

BACKGROUND: BRCA1 or BRCA2 (BRCA1/2) mutated ovarian carcinomas may originate in the fallopian tube. We investigated alterations in BRCA1/2 tubal epithelium to define the molecular pathogenesis of these carcinomas. METHODS: Tubal epithelium was evaluated from 31 BRCA1/2 mutation carriers with gyneco...

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Hauptverfasser: Norquist, Barbara M., Garcia, Rochelle L., Allison, Kimberly H., Jokinen, Chris H., Kernochan, Lauren E., Pizzi, Catherine C., Barrow, Bethany J., Goff, Barbara A., Swisher, Elizabeth M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975783/
https://ncbi.nlm.nih.gov/pubmed/20665887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.25439
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