CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity

Transplantable murine models of ovarian high grade serous carcinoma (HGSC) remain an important research tool. We previously showed that ID8, a widely-used syngeneic model of ovarian cancer, lacked any of the frequent mutations in HGSC, and used CRISPR/Cas9 gene editing to generate derivatives with d...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Walton, Josephine B., Farquharson, Malcolm, Mason, Susan, Port, Jennifer, Kruspig, Bjorn, Dowson, Suzanne, Stevenson, David, Murphy, Daniel, Matzuk, Martin, Kim, Jaeyeon, Coffelt, Seth, Blyth, Karen, McNeish, Iain A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715106/
https://ncbi.nlm.nih.gov/pubmed/29203787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17119-1
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items