6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M(1) mAChR: The Determinants of Allosteric Activity

Targeting allosteric sites of the M(1) muscarinic acetylcholine receptor (mAChR) is an enticing approach to overcome the lack of receptor subtype selectivity observed with orthosteric ligands. This is a promising strategy for obtaining novel therapeutics to treat cognitive deficits observed in Alzhe...

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Veröffentlicht in:ACS Chem Neurosci
Hauptverfasser: Jörg, Manuela, van der Westhuizen, Emma T., Khajehali, Elham, Burger, Wessel A. C., White, Jonathan M., Choy, Kwok H. C., Tobin, Andrew B., Sexton, Patrick M., Valant, Celine, Capuano, Ben, Christopoulos, Arthur, Scammells, Peter J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616175/
https://ncbi.nlm.nih.gov/pubmed/30547573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00613
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