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6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M(1) mAChR: The Determinants of Allosteric Activity
Targeting allosteric sites of the M(1) muscarinic acetylcholine receptor (mAChR) is an enticing approach to overcome the lack of receptor subtype selectivity observed with orthosteric ligands. This is a promising strategy for obtaining novel therapeutics to treat cognitive deficits observed in Alzhe...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ACS Chem Neurosci |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7616175/ https://ncbi.nlm.nih.gov/pubmed/30547573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00613 |
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