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6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M(1) mAChR: The Determinants of Allosteric Activity

Targeting allosteric sites of the M(1) muscarinic acetylcholine receptor (mAChR) is an enticing approach to overcome the lack of receptor subtype selectivity observed with orthosteric ligands. This is a promising strategy for obtaining novel therapeutics to treat cognitive deficits observed in Alzhe...

詳細記述

保存先:
書誌詳細
出版年:ACS Chem Neurosci
主要な著者: Jörg, Manuela, van der Westhuizen, Emma T., Khajehali, Elham, Burger, Wessel A. C., White, Jonathan M., Choy, Kwok H. C., Tobin, Andrew B., Sexton, Patrick M., Valant, Celine, Capuano, Ben, Christopoulos, Arthur, Scammells, Peter J.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616175/
https://ncbi.nlm.nih.gov/pubmed/30547573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00613
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