6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M(1) mAChR: The Determinants of Allosteric Activity

Targeting allosteric sites of the M(1) muscarinic acetylcholine receptor (mAChR) is an enticing approach to overcome the lack of receptor subtype selectivity observed with orthosteric ligands. This is a promising strategy for obtaining novel therapeutics to treat cognitive deficits observed in Alzhe...

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Bibliografski detalji
Izdano u:ACS Chem Neurosci
Glavni autori: Jörg, Manuela, van der Westhuizen, Emma T., Khajehali, Elham, Burger, Wessel A. C., White, Jonathan M., Choy, Kwok H. C., Tobin, Andrew B., Sexton, Patrick M., Valant, Celine, Capuano, Ben, Christopoulos, Arthur, Scammells, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616175/
https://ncbi.nlm.nih.gov/pubmed/30547573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00613
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