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6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M(1) mAChR: The Determinants of Allosteric Activity
Targeting allosteric sites of the M(1) muscarinic acetylcholine receptor (mAChR) is an enticing approach to overcome the lack of receptor subtype selectivity observed with orthosteric ligands. This is a promising strategy for obtaining novel therapeutics to treat cognitive deficits observed in Alzhe...
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| 出版年: | ACS Chem Neurosci |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7616175/ https://ncbi.nlm.nih.gov/pubmed/30547573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00613 |
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