Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach

Mycobacterium abscessus (Mab) has emerged as a challenging threat to individuals with cystic fibrosis. Infections caused by this pathogen are often impossible to treat due to the intrinsic antibiotic resistance leading to lung malfunction and eventually death. Therefore, there is an urgent need to d...

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Publicado no:ACS Infect Dis
Main Authors: Charoensutthivarakul, Sitthivut, Thomas, Sherine E., Curran, Amy, Brown, Karen P., Belardinelli, Juan M., Whitehouse, Andrew J., Acebrón-García-de-Eulate, Marta, Sangan, Jaspar, Gramani, Subramanian G., Jackson, Mary, Mendes, Vitor, Andres Floto, R., Blundell, Tom L., Coyne, Anthony G., Abell, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614835/
https://ncbi.nlm.nih.gov/pubmed/35037462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.1c00432
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