Development of Inhibitors against Mycobacterium abscessus tRNA (m(1)G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

[Image: see text] Mycobacterium abscessus (Mab) is a rapidly growing species of multidrug-resistant nontuberculous mycobacteria that has emerged as a growing threat to individuals with cystic fibrosis and other pre-existing chronic lung diseases. Mab pulmonary infections are difficult, or sometimes...

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Udgivet i:J Med Chem
Main Authors: Whitehouse, Andrew J., Thomas, Sherine E., Brown, Karen P., Fanourakis, Alexander, Chan, Daniel S.-H., Libardo, M. Daben J., Mendes, Vitor, Boshoff, Helena I. M., Floto, R. Andres, Abell, Chris, Blundell, Tom L., Coyne, Anthony G.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691401/
https://ncbi.nlm.nih.gov/pubmed/31282680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00809
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