Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

Translational frameshift errors are often deleterious to the synthesis of functional proteins and could therefore be promoted therapeutically to kill bacteria. TrmD (tRNA-(N(1)G37) methyltransferase) is an essential tRNA modification enzyme in bacteria that prevents +1 errors in the reading frame du...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Thomas, Sherine E, Whitehouse, Andrew J, Brown, Karen, Burbaud, Sophie, Belardinelli, Juan M, Sangen, Jasper, Lahiri, Ramanuj, Libardo, Mark Daben J, Gupta, Pooja, Malhotra, Sony, Boshoff, Helena I M, Jackson, Mary, Abell, Chris, Coyne, Anthony G, Blundell, Tom L, Floto, Rodrigo Andres, Mendes, Vítor
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641325/
https://ncbi.nlm.nih.gov/pubmed/32602532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa539
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