Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

Translational frameshift errors are often deleterious to the synthesis of functional proteins and could therefore be promoted therapeutically to kill bacteria. TrmD (tRNA-(N(1)G37) methyltransferase) is an essential tRNA modification enzyme in bacteria that prevents +1 errors in the reading frame du...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Thomas, Sherine E, Whitehouse, Andrew J, Brown, Karen, Burbaud, Sophie, Belardinelli, Juan M, Sangen, Jasper, Lahiri, Ramanuj, Libardo, Mark Daben J, Gupta, Pooja, Malhotra, Sony, Boshoff, Helena I M, Jackson, Mary, Abell, Chris, Coyne, Anthony G, Blundell, Tom L, Floto, Rodrigo Andres, Mendes, Vítor
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641325/
https://ncbi.nlm.nih.gov/pubmed/32602532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa539
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