Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach

Mycobacterium abscessus (Mab) has emerged as a challenging threat to individuals with cystic fibrosis. Infections caused by this pathogen are often impossible to treat due to the intrinsic antibiotic resistance leading to lung malfunction and eventually death. Therefore, there is an urgent need to d...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Charoensutthivarakul, Sitthivut, Thomas, Sherine E., Curran, Amy, Brown, Karen P., Belardinelli, Juan M., Whitehouse, Andrew J., Acebrón-García-de-Eulate, Marta, Sangan, Jaspar, Gramani, Subramanian G., Jackson, Mary, Mendes, Vitor, Andres Floto, R., Blundell, Tom L., Coyne, Anthony G., Abell, Chris
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2022
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614835/
https://ncbi.nlm.nih.gov/pubmed/35037462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.1c00432
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