Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach

Mycobacterium abscessus (Mab) has emerged as a challenging threat to individuals with cystic fibrosis. Infections caused by this pathogen are often impossible to treat due to the intrinsic antibiotic resistance leading to lung malfunction and eventually death. Therefore, there is an urgent need to d...

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Detaylı Bibliyografya
Yayımlandı:ACS Infect Dis
Asıl Yazarlar: Charoensutthivarakul, Sitthivut, Thomas, Sherine E., Curran, Amy, Brown, Karen P., Belardinelli, Juan M., Whitehouse, Andrew J., Acebrón-García-de-Eulate, Marta, Sangan, Jaspar, Gramani, Subramanian G., Jackson, Mary, Mendes, Vitor, Andres Floto, R., Blundell, Tom L., Coyne, Anthony G., Abell, Chris
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2022
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614835/
https://ncbi.nlm.nih.gov/pubmed/35037462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.1c00432
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