Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach

Mycobacterium abscessus (Mab) has emerged as a challenging threat to individuals with cystic fibrosis. Infections caused by this pathogen are often impossible to treat due to the intrinsic antibiotic resistance leading to lung malfunction and eventually death. Therefore, there is an urgent need to d...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:ACS Infect Dis
Main Authors: Charoensutthivarakul, Sitthivut, Thomas, Sherine E., Curran, Amy, Brown, Karen P., Belardinelli, Juan M., Whitehouse, Andrew J., Acebrón-García-de-Eulate, Marta, Sangan, Jaspar, Gramani, Subramanian G., Jackson, Mary, Mendes, Vitor, Andres Floto, R., Blundell, Tom L., Coyne, Anthony G., Abell, Chris
Format: Artigo
Jezik:Inglês
Izdano: 2022
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614835/
https://ncbi.nlm.nih.gov/pubmed/35037462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.1c00432
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