Crystal structure and catalytic mechanism of the essential m(1)G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa

The tRNA (m(1)G37) methyltransferase TrmD catalyzes m(1)G formation at position 37 in many tRNA isoacceptors and is essential in most bacteria, which positions it as a target for antibiotic development. In spite of its crucial role, little is known about TrmD in Pseudomonas aeruginosa (PaTrmD), an i...

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Publicado no:RNA
Main Authors: Jaroensuk, Juthamas, Wong, Yee Hwa, Zhong, Wenhe, Liew, Chong Wai, Maenpuen, Somchart, Sahili, Abbas E., Atichartpongkul, Sopapan, Chionh, Yok Hian, Nah, Qianhui, Thongdee, Narumon, McBee, Megan E., Prestwich, Erin G., DeMott, Michael S., Chaiyen, Pimchai, Mongkolsuk, Skorn, Dedon, Peter C., Lescar, Julien, Fuangthong, Mayuree
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795141/
https://ncbi.nlm.nih.gov/pubmed/31399541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.066746.118
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