The mechanical stability of proteins regulates their translocation rate into the cell nucleus

The translocation of mechanosensitive transcription factors (TFs) across the nuclear envelope is a crucial step in cellular mechanotransduction. Yet the molecular mechanisms by which external mechanical cues control the nuclear shuttling dynamics of TFs through the nuclear pore complex (NPC) to acti...

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Publicat a:Nat Phys
Autors principals: Infante, Elvira, Stannard, Andrew, Board, Stephanie J., Rico-Lastres, Palma, Panagaki, Fani, Beedle, Amy E.M., Rajan, Vinoth Sundar, Rostkova, Elena, Lezamiz, Ainhoa, Wang, Yong Jian, Breen, Samuel Gulaidi, Shanahan, Catherine, Roca-Cusachs, Pere, Garcia-Manyes, Sergi
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614795/
https://ncbi.nlm.nih.gov/pubmed/37484710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41567-019-0551-3
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