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The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins

Understanding the directionality and sequence of protein unfolding is crucial to elucidate the underlying folding free energy landscape. An extra layer of complexity is added in metalloproteins, where a metal cofactor participates in the correct, functional fold of the protein. However, the precise...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Beedle, Amy E. M., Lezamiz, Ainhoa, Stirnemann, Guillaume, Garcia-Manyes, Sergi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532836/
https://ncbi.nlm.nih.gov/pubmed/26235284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8894
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