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The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins

Understanding the directionality and sequence of protein unfolding is crucial to elucidate the underlying folding free energy landscape. An extra layer of complexity is added in metalloproteins, where a metal cofactor participates in the correct, functional fold of the protein. However, the precise...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Beedle, Amy E. M., Lezamiz, Ainhoa, Stirnemann, Guillaume, Garcia-Manyes, Sergi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532836/
https://ncbi.nlm.nih.gov/pubmed/26235284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8894
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