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Structural snapshot of a β-arrestin-biased receptor

Atypical chemokine receptor sub-type 3 (ACKR3), a chemokine receptor, couples selectively to β-arrestins (βarrs) but not to G proteins despite having seven transmembrane (7TM) helix architecture. Yen et al. present cryogenic-electron microscopy (cryoEM) structures of agonist-bound ACKR3, elucidating...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Trends Pharmacol Sci
Prif Awduron: Sarma, Parishmita, Banerjee, Ramanuj, Shukla, Arun K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2023
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614537/
https://ncbi.nlm.nih.gov/pubmed/36057461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2022.08.005
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