Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation

Agonist-induced GPCR phosphorylation is a key determinant for the binding and activation of β-arrestins (βarrs). However, it is not entirely clear how different GPCRs harboring divergent phosphorylation patterns impart converging active conformation on βarrs leading to broadly conserved functional r...

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Publicado en:Mol Cell
Autores principales: Maharana, Jagannath, Sarma, Parishmita, Yadav, Manish K., Saha, Sayantan, Singh, Vinay, Saha, Shirsha, Chami, Mohamed, Banerjee, Ramanuj, Shukla, Arun K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2023
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615930/
https://ncbi.nlm.nih.gov/pubmed/37209686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2023.04.025
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