Structures of α-synuclein filaments from human brains with Lewy pathology

Parkinson’s disease (PD) is the most common movement disorder, with resting tremor, rigidity, bradykinesia and postural instability being major symptoms (1). Neuropathologically, it is characterised by the presence of abundant filamentous inclusions of α-synuclein in the form of Lewy bodies and Lewy...

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Publicado no:Nature
Main Authors: Yang, Yang, Shi, Yang, Schweighauser, Manuel, Zhang, Xianjun, Kotecha, Abhay, Murzin, Alexey G., Garringer, Holly J., Cullinane, Patrick W., Saito, Yuko, Foroud, Tatiana, Warner, Thomas T., Hasegawa, Kazuko, Vidal, Ruben, Murayama, Shigeo, Revesz, Tamas, Ghetti, Bernardino, Hasegawa, Masato, Lashley, Tammaryn, Scheres, Sjors H.W., Goedert, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613749/
https://ncbi.nlm.nih.gov/pubmed/36108674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-022-05319-3
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