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Structures of α-synuclein filaments from human brains with Lewy pathology

Parkinson’s disease (PD) is the most common movement disorder, with resting tremor, rigidity, bradykinesia and postural instability being major symptoms (1). Neuropathologically, it is characterised by the presence of abundant filamentous inclusions of α-synuclein in the form of Lewy bodies and Lewy...

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Podrobná bibliografie
Vydáno v:Nature
Hlavní autoři: Yang, Yang, Shi, Yang, Schweighauser, Manuel, Zhang, Xianjun, Kotecha, Abhay, Murzin, Alexey G., Garringer, Holly J., Cullinane, Patrick W., Saito, Yuko, Foroud, Tatiana, Warner, Thomas T., Hasegawa, Kazuko, Vidal, Ruben, Murayama, Shigeo, Revesz, Tamas, Ghetti, Bernardino, Hasegawa, Masato, Lashley, Tammaryn, Scheres, Sjors H.W., Goedert, Michel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2022
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613749/
https://ncbi.nlm.nih.gov/pubmed/36108674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-022-05319-3
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