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Transcriptional neighborhoods regulate transcript isoform lengths and expression levels

Sequence features of genes and their flanking regulatory regions are determinants of RNA transcript isoform expression and have been used as context-independent, plug-and-play modules in synthetic biology. However, genetic context, including the adjacent transcriptional environment, also influences...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Science
Main Authors: Brooks, Aaron N., Hughes, Amanda L., Clauder-Münster, Sandra, Mitchell, Leslie A., Boeke, Jef D., Steinmetz, Lars M.
Format: Artigo
Jezik:Inglês
Izdano: 2022
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613581/
https://ncbi.nlm.nih.gov/pubmed/35239377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abg0162
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