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Transcriptional neighborhoods regulate transcript isoform lengths and expression levels

Sequence features of genes and their flanking regulatory regions are determinants of RNA transcript isoform expression and have been used as context-independent, plug-and-play modules in synthetic biology. However, genetic context, including the adjacent transcriptional environment, also influences...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Brooks, Aaron N., Hughes, Amanda L., Clauder-Münster, Sandra, Mitchell, Leslie A., Boeke, Jef D., Steinmetz, Lars M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613581/
https://ncbi.nlm.nih.gov/pubmed/35239377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abg0162
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