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Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes

Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular diseases. Comparative analysis of RNA isoforms at the genome-wide scale has been difficult. Here, we establish an experi...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Zhu, Chenchen, Wu, Jingyan, Sun, Han, Briganti, Francesca, Meder, Benjamin, Wei, Wu, Steinmetz, Lars M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270901/
https://ncbi.nlm.nih.gov/pubmed/34244519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24484-z
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