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Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes

Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular diseases. Comparative analysis of RNA isoforms at the genome-wide scale has been difficult. Here, we establish an experi...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Zhu, Chenchen, Wu, Jingyan, Sun, Han, Briganti, Francesca, Meder, Benjamin, Wei, Wu, Steinmetz, Lars M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270901/
https://ncbi.nlm.nih.gov/pubmed/34244519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24484-z
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