DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

The survival of children with diffuse intrinsic pontine glioma (DIPG) remains dismal, with new treatments desperately needed. In a prospective biopsy-stratified clinical trial, we combined detailed molecular profiling and drug screening in newly established patient-derived models in vitro and in viv...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cancer Discov
Κύριοι συγγραφείς: Izquierdo, Elisa, Carvalho, Diana M., Mackay, Alan, Temelso, Sara, Boult, Jessica K.R., Pericoli, Giulia, Fernandez, Elisabet, Das, Molina, Molinari, Valeria, Grabovska, Yura, Rogers, Rebecca F., Ajmone-Cat, Maria Antonietta, Proszek, Paula Z., Stubbs, Mark, Depani, Sarita, O'Hare, Patricia, Yu, Lu, Roumelioti, Georgia, Choudhary, Jyoti S., Clarke, Matthew, Fairchild, Amy R., Jacques, Thomas S., Grundy, Richard G., Howell, Lisa, Picton, Susan, Adamski, Jenny, Wilson, Shaun, Gray, Juliet C., Zebian, Bassel, Marshall, Lynley V., Carceller, Fernando, Grill, Jacques, Vinci, Maria, Robinson, Simon P., Hubank, Michael, Hargrave, Darren, Jones, Chris
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Association for Cancer Research 2022
Θέματα:
Research Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612484/
https://ncbi.nlm.nih.gov/pubmed/34737188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0930
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