DIPG-25. GENETIC ALTERATIONS TARGETING THE MAPK PATHWAY CONFERS PRECLINICAL SENSITIVITY TO TRAMETINIB IN A CO-CLINICAL TRIAL IN DIPG

The survival of children with DIPG remains dismal, and new treatments are desperately needed. The development of patient-specific in vitro and in vivo models represents one such opportunity, however the time taken to establish such models and the rapid disease progression has been thought to limit t...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Izquierdo, Elisa, Carvalho, Diana, Boult, Jessica, Mackay, Alan, Temelso, Sara, Molinari, Valeria, Stubbs, Mark, Burke, Rosemary, Depani, Sarita, O’Hare, Patricia, Robinson, Simon, Hubank, Michael, Hargrave, Darren, Jones, Chris
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
Ämnen:
Diffuse Intrinsic Pontine Glioma (DIPG)
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477199/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.046
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