MODL-19. DIPG HARBOUR ALTERATIONS TARGETABLE BY MEK INHIBITORS, WITH ACQUIRED RESISTANCE MECHANISMS OVERCOME BY COMBINATORIAL UP- OR DOWN-STREAM INHIBITION

The survival of children with DIPG remains dismal, with new treatments desperately needed. In the era of precision medicine, targeted therapies represent an exciting treatment opportunity, yet resistance can rapidly emerge, playing an important role in treatment failure. In a prospective biopsy-stra...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Izquierdo, Elisa, Carvalho, Diana, Mackay, Alan, Temelso, Sara, Boult, Jessica K R, Molinari, Valeria, Stubbs, Mark, Depani, Sarita, O’Hare, Patricia, Robinson, Simon P, Hubank, Michael, Hargrave, Darren, Jones, Chris
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Preclinical Models/Experimental Therapy/Drug Discovery
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715767/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.592
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