MODL-19. DIPG HARBOUR ALTERATIONS TARGETABLE BY MEK INHIBITORS, WITH ACQUIRED RESISTANCE MECHANISMS OVERCOME BY COMBINATORIAL UP- OR DOWN-STREAM INHIBITION

The survival of children with DIPG remains dismal, with new treatments desperately needed. In the era of precision medicine, targeted therapies represent an exciting treatment opportunity, yet resistance can rapidly emerge, playing an important role in treatment failure. In a prospective biopsy-stra...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Izquierdo, Elisa, Carvalho, Diana, Mackay, Alan, Temelso, Sara, Boult, Jessica K R, Molinari, Valeria, Stubbs, Mark, Depani, Sarita, O’Hare, Patricia, Robinson, Simon P, Hubank, Michael, Hargrave, Darren, Jones, Chris
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Preclinical Models/Experimental Therapy/Drug Discovery
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715767/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.592
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