MODL-20. A BIOBANK OF ~100 PATIENT-DERIVED MODELS REPRESENTING BIOLOGICAL HETEROGENEITY AND DISTINCT THERAPEUTIC DEPENDENCIES IN PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

Paediatric high-grade glioma comprise multiple biological and clinical subgroups, the majority of which urgently require novel therapies. Patient-derived models represent useful tools for mechanistic and preclinical investigations based upon their retention of key genetic/epigenetic features and the...

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Foilsithe in:Neuro Oncol
Main Authors: Carvalho, Diana, Mackay, Alan, Temelso, Sara, Izquierdo, Elisa, Fernandez, Elisabet Potente, Rogers, Rebecca, Boult, Jessica, Salom, Janat Fazal, Simon, Natalie, Clarke, Matthew, Molinari, Valeria, Kessler, Ketty, Burford, Anna, Bjerke, Lynn, Fofana, Mariama, Hubank, Michael, Pears, Jane, Moore, Andrew, Carcaboso, Angel Montero, Marshall, Lynley, Carceller, Fernando, Robinson, Simon, Hargrave, Darren, Vinci, Maria, Jones, Chris
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Preclinical Models/Experimental Therapy/Drug Discovery
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715119/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.593
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