PDTM-33. ATRX LOSS CONFERS ENHANCED SENSITIVITY TO COMBINED PARP INHIBITION AND RADIOTHERAPY IN PAEDIATRIC GLIOBLASTOMA MODELS

Paediatric high grade glioma (pHGG) are defined by recurrent mutations in H3 histones, as well as frequent alterations in the SWI/SNF chromatin remodelling gene ATRX (α-thalassemia mental retardation X-linked), although the precise role of ATRX in tumorigenesis remains unclear. We sought to explore...

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Publicado no:Neuro Oncol
Main Authors: Fazal Salom, Janat, Bjerke, Lynn, Carvalho, Diana, Boult, Jessica, Mackay, Alan, Pemberton, Helen, Molinari, Valeria, Clarke, Matthew, Vinci, Maria, Carceller, Fernando, Marshall, Lynley, Moore, Andrew, Montero Carcaboso, Angel, Lord, Chris, Robinson, Simon, Hargrave, Darren, Jones, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217705/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.873
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