HGG-37. PAEDIATRIC GLIOBLASTOMA CELLS SHOW CRITICAL DEPENDENCIES ON EPIGENOMIC AND EPITRANSCRIPTOMIC CONTROL OF GENE EXPRESSION BY H3.3G34R/V MUTATIONS

H3.3G34R/V mutations are restricted to glioblastomas of the cerebral hemispheres, and occur predominantly in adolescents and young adults. We had previously shown these mutations to result in a global re-organisation of the activating mark H3K36me3 to drive transcription of key developmental transcr...

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Библиографические подробности
Опубликовано в: :Neuro Oncol
Главные авторы: Bjerke, Lynn, Mackay, Alan, Rogers, Rebecca, Grabovska, Yura, Molinari, Valeria, Temelso, Sara, Cole, Kristina, Waanders, Angela, Carcaboso, Angel Montero, Vinci, Maria, Jones, Chris
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
High Grade Glioma
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715655/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.318
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