HGG-33. EXPLOITING METABOLIC DEFECTS WITH NAMPT INHIBITORS IN DIPG

Diffuse intrinsic pontine glioma (DIPG) are universally lethal pediatric brain tumors with limited treatment options. We recently performed synthetic lethal drug screen with a panel of DNA repair and metabolic inhibitors in vitro, in patient-derived DIPG cells and isogenic cell lines engineered to c...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Muraleedharan, Ranjithmenon, Heer, Collin, Sundam, Ranjini, Brenner, Charles
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
High Grade Gliomas
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168214/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.097
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