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HGG-07. MUTATIONS IN ATRX INCREASE GENETIC INSTABILITY AND SENSITIVITY TO PARP INHIBITORS IN PAEDIATRIC GLIOBLASTOMA CELLS
Paediatric high grade glioma (pHGG) and DIPG are defined by recurrent mutations in H3 histones, as well as frequent alterations in the chromatin remodeling protein ATRX. This is strongly associated with the alternative lengthening of telomeres (ALT) phenotype, but their precise interaction with hist...
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| Publicat a: | Neuro Oncol |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5475084/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.096 |
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