HGG-07. MUTATIONS IN ATRX INCREASE GENETIC INSTABILITY AND SENSITIVITY TO PARP INHIBITORS IN PAEDIATRIC GLIOBLASTOMA CELLS

Paediatric high grade glioma (pHGG) and DIPG are defined by recurrent mutations in H3 histones, as well as frequent alterations in the chromatin remodeling protein ATRX. This is strongly associated with the alternative lengthening of telomeres (ALT) phenotype, but their precise interaction with hist...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Neuro Oncol
मुख्य लेखकों: Fazal-Salom, Janat, Vinci, Mara, Carvalho, Diana, Pemberton, Helen, Pettit, Steve, Lord, Christopher, Mackay, Alan, Bjerke, Lynn, Jones, Chris
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2017
विषय:
Abstracts
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475084/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.096
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