HGG-07. MUTATIONS IN ATRX INCREASE GENETIC INSTABILITY AND SENSITIVITY TO PARP INHIBITORS IN PAEDIATRIC GLIOBLASTOMA CELLS

Paediatric high grade glioma (pHGG) and DIPG are defined by recurrent mutations in H3 histones, as well as frequent alterations in the chromatin remodeling protein ATRX. This is strongly associated with the alternative lengthening of telomeres (ALT) phenotype, but their precise interaction with hist...

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Publicado no:Neuro Oncol
Main Authors: Fazal-Salom, Janat, Vinci, Mara, Carvalho, Diana, Pemberton, Helen, Pettit, Steve, Lord, Christopher, Mackay, Alan, Bjerke, Lynn, Jones, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475084/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.096
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