MODL-20. A BIOBANK OF ~100 PATIENT-DERIVED MODELS REPRESENTING BIOLOGICAL HETEROGENEITY AND DISTINCT THERAPEUTIC DEPENDENCIES IN PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

Paediatric high-grade glioma comprise multiple biological and clinical subgroups, the majority of which urgently require novel therapies. Patient-derived models represent useful tools for mechanistic and preclinical investigations based upon their retention of key genetic/epigenetic features and the...

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Pubblicato in:Neuro Oncol
Autori principali: Carvalho, Diana, Mackay, Alan, Temelso, Sara, Izquierdo, Elisa, Fernandez, Elisabet Potente, Rogers, Rebecca, Boult, Jessica, Salom, Janat Fazal, Simon, Natalie, Clarke, Matthew, Molinari, Valeria, Kessler, Ketty, Burford, Anna, Bjerke, Lynn, Fofana, Mariama, Hubank, Michael, Pears, Jane, Moore, Andrew, Carcaboso, Angel Montero, Marshall, Lynley, Carceller, Fernando, Robinson, Simon, Hargrave, Darren, Vinci, Maria, Jones, Chris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Preclinical Models/Experimental Therapy/Drug Discovery
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715119/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.593
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